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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732790
Species: Homo sapiens
RGD Object: Gene
Symbol: LMNA
Name: lamin A/C
Acc ID: CHEBI:45906
Term: suramin
Definition: A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Chemical ID: MESH:D013498
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
LMNAmultiple interactionsEXP 6480464CTDSuramin inhibits the reaction [LMNA protein binds to and results in increased activity of SIRT1 protein]PMID:23217256
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