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REFERENCE - CHEMICAL INTERACTIONS REPORT

RGD ID: 727431
Species: All species
RGD Object: Reference
Acc ID: CHEBI:45906
Term: suramin
Definition: A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Chemical ID: MESH:D013498
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
P2rx1affects bindingEXP 727431RGDSuramin binds to P2rx1 protein 
P2rx5affects transportEXP 727431RGDSuramin affects transport ion flux of P2rx5 receptor 
P2RX1affects bindingISOP2rx1 (Rattus norvegicus)727431RGDSuramin binds to P2rx1 protein 
P2rx1affects bindingISOP2rx1 (Rattus norvegicus)727431RGDSuramin binds to P2rx1 protein 
P2RX5affects transportISOP2rx5 (Rattus norvegicus)727431RGDSuramin affects transport ion flux of P2rx5 receptor 
P2rx5affects transportISOP2rx5 (Rattus norvegicus)727431RGDSuramin affects transport ion flux of P2rx5 receptor 
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