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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3811
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tacr1
Name: tachykinin receptor 1
Acc ID: CHEBI:45906
Term: suramin
Definition: A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Chemical ID: MESH:D013498
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tacr1multiple interactionsEXP 6480464CTDSuramin inhibits the reaction [Cyclophosphamide results in increased expression of TACR1 protein]PMID:23666265
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