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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732407
Species: Homo sapiens
RGD Object: Gene
Symbol: AKT2
Name: AKT serine/threonine kinase 2
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKT2affects response to substanceEXP 6480464CTDAKT2 protein affects the susceptibility to PaclitaxelPMID:18071906
AKT2increases phosphorylationEXP 6480464CTDPaclitaxel results in increased phosphorylation of AKT2 proteinPMID:18071906
AKT2decreases expressionISOAkt2 (Rattus norvegicus)6480464CTDPaclitaxel results in decreased expression of AKT2 mRNAPMID:36966900
AKT2multiple interactionsISOAkt2 (Rattus norvegicus)6480464CTDHesperidin inhibits the reaction [Paclitaxel results in decreased expression of AKT2 mRNA]PMID:36966900
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