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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732106
Species: Mus musculus
RGD Object: Gene
Symbol: Fadd
Name: Fas associated via death domain
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Faddincreases expressionISOFADD (Homo sapiens)6480464CTDPaclitaxel results in increased expression of FADD mRNAPMID:18058816
Faddincreases phosphorylationISOFADD (Homo sapiens)6480464CTDPaclitaxel results in increased phosphorylation of FADD proteinPMID:16450001
Faddmultiple interactionsISOFADD (Homo sapiens)6480464CTDpyrazolanthrone inhibits the reaction [Paclitaxel results in increased phosphorylation of FADD protein]PMID:16450001
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