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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730895
Species: Mus musculus
RGD Object: Gene
Symbol: Il18
Name: interleukin 18
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Il18increases expressionISOIL18 (Homo sapiens)6480464CTDPaclitaxel results in increased expression of IL18 mRNAPMID:31993881
Il18increases secretionISOIL18 (Homo sapiens)6480464CTDPaclitaxel results in increased secretion of IL18 proteinPMID:31993881
Il18multiple interactionsISOIL18 (Homo sapiens)6480464CTD[Cisplatin co-treated with Paclitaxel] results in increased expression of IL18 mRNA; benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paclitaxel results in increased expression of IL18 mRNA]; benzyloxycarbonyltyrosyl-valyl-alanyl-aspartic acid fluoromethyl ketone inhibits the reaction [Paclitaxel results in increased secretion of IL18 protein]PMID:20705681 PMID:31993881
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