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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730893
Species: Mus musculus
RGD Object: Gene
Symbol: Nfkb1
Name: nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkb1multiple interactionsEXP 6480464CTDITGAM protein affects the reaction [Paclitaxel affects the localization of and results in increased activity of [NFKB1 protein binds to RELA protein]]; Paclitaxel affects the localization of and results in increased activity of [NFKB1 protein binds to RELA protein]PMID:11123339
Nfkb1increases expressionISONfkb1 (Rattus norvegicus)6480464CTDPaclitaxel results in increased expression of NFKB1 mRNAPMID:35921949 PMID:36966900
Nfkb1multiple interactionsISONfkb1 (Rattus norvegicus)6480464CTDHesperidin inhibits the reaction [Paclitaxel results in increased expression of NFKB1 mRNA]PMID:35921949 PMID:36966900
Nfkb1multiple interactionsISONFKB1 (Homo sapiens)6480464CTD[Paclitaxel co-treated with Metformin] results in decreased expression of NFKB1 mRNA; Curcumin inhibits the reaction [Paclitaxel results in increased activity of NFKB1 protein]PMID:16243823 PMID:29309887
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