GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | ABCB1 | affects metabolic processing | EXP | | 6480464 | CTD | ABCB1 gene polymorphism affects the metabolism of Paclitaxel | PMID:15901749 | ABCB1 | affects response to substance | EXP | | 6480464 | CTD | ABCB1 gene SNP affects the susceptibility to Paclitaxel; ABCB1 protein affects the susceptibility to Paclitaxel | PMID:16950614 PMID:33974899 | ABCB1 | decreases response to substance | EXP | | 6480464 | CTD | ABCB1 mRNA results in decreased susceptibility to Paclitaxel; ABCB1 protein results in decreased susceptibility to Paclitaxel | PMID:15252144 PMID:15990222 PMID:16322897 PMID:16831368 PMID:17284363 PMID:17697605 PMID:20196146 PMID:22233293 PMID:22792399 PMID:25058526 PMID:25268938 PMID:26689174 PMID:27664577 PMID:29625142 PMID:32497533 PMID:37259354 | ABCB1 | decreases uptake | EXP | | 6480464 | CTD | ABCB1 protein results in decreased uptake of Paclitaxel | PMID:10617675 | ABCB1 | increases activity | EXP | | 6480464 | CTD | Paclitaxel results in increased activity of ABCB1 protein | PMID:14512701 | ABCB1 | increases export | EXP | | 6480464 | CTD | ABCB1 protein results in increased export of Paclitaxel | PMID:28031414 | ABCB1 | increases expression | EXP | | 6480464 | CTD | Paclitaxel results in increased expression of ABCB1 mRNA; Paclitaxel results in increased expression of ABCB1 protein | PMID:15650019 PMID:15990222 PMID:16819505 PMID:17284363 PMID:20041327 PMID:21833476 PMID:23707768 PMID:31628941 | ABCB1 | increases response to substance | EXP | | 6480464 | CTD | ABCB1 mRNA results in increased susceptibility to Paclitaxel | PMID:15239142 | ABCB1 | increases transport | EXP | | 6480464 | CTD | ABCB1 protein results in increased transport of Paclitaxel | PMID:12708479 | ABCB1 | multiple interactions | EXP | | 6480464 | CTD | 6-OH-BDE-47 inhibits the reaction [ABCB1 protein results in increased export of Paclitaxel]; [Calcitriol co-treated with Curcumin] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; [Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 mRNA; [Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 protein; [Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Paclitaxel]] which results in decreased susceptibility to Paclitaxel; [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; [Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein; [CXCL8 results in increased expression of ABCB1 mRNA] which results in decreased susceptibility to Paclitaxel; [CXCL8 results in increased expression of ABCB1 protein] which results in decreased susceptibility to Paclitaxel; [Cyclosporine results in decreased activity of ABCB1 protein] which results in increased susceptibility to Paclitaxel; [Paclitaxel co-treated with IL6 protein] results in increased expression of ABCB1 protein; [Paclitaxel results in increased activity of NR1I2 protein] which results in increased expression of ABCB1 mRNA; [Paclitaxel results in increased expression of ABCB1] which results in decreased susceptibility to Cisplatin; [Paclitaxel results in increased expression of ABCB1] which results in decreased susceptibility to Doxorubicin; [Paclitaxel results in increased expression of ABCB1] which results in decreased susceptibility to Fluorouracil; [Paclitaxel results in increased expression of ABCB1] which results in decreased susceptibility to Vincristine; [valspodar results in decreased activity of ABCB1 protein] which results in increased susceptibility to Paclitaxel; [Verapamil results in decreased activity of ABCB1 protein] which results in increased susceptibility to Paclitaxel; ABCB1 protein affects the reaction [acetochlor results in increased susceptibility to Paclitaxel]; ABCB1 protein affects the reaction [alachlor results in increased susceptibility to Paclitaxel]; ABCB1 protein affects the reaction [metolachlor results in increased susceptibility to Paclitaxel]; ABCB1 protein results in increased export of and affects the susceptibility to Paclitaxel; Calcitriol inhibits the reaction [[Curcumin co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Calcitriol inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Carvedilol inhibits the reaction [ABCB1 protein results in increased transport of Paclitaxel]; CEP 33779 inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; cinchonine analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; cinchonine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Crizotinib inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin analog inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [[Calcitriol co-treated with Paclitaxel] results in increased expression of ABCB1 protein]; Curcumin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; HIF1A protein affects the reaction [[Paclitaxel co-treated with IL6 protein] results in increased expression of ABCB1 protein]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of ABCB1 mRNA]; Ketoconazole inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; NR1I2 protein promotes the reaction [Paclitaxel results in increased expression of and results in increased activity of ABCB1 protein]; Paclitaxel results in increased expression of and binds to and results in increased activity of ABCB1 protein; pinostrobin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; propiconazole inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Quinidine inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; tectochrysin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Verapamil inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; Verapamil inhibits the reaction [ABCB1 protein results in increased transport of Paclitaxel] | PMID:12708479 PMID:16819505 PMID:18433974 PMID:18673531 PMID:20041327 PMID:20196146 PMID:21742513 PMID:21833476 PMID:22233293 PMID:25058526 PMID:25268938 PMID:26689174 PMID:28031414 PMID:29341321 PMID:29625142 PMID:31628941 PMID:37259354 | ABCB1 | affects uptake | ISO | Abcb1a (Mus musculus) | 6480464 | CTD | ABCB1A protein affects the uptake of Paclitaxel | PMID:10562306 | ABCB1 | increases expression | ISO | Abcb1a (Mus musculus) | 6480464 | CTD | Paclitaxel results in increased expression of ABCB1 protein | PMID:31628941 | ABCB1 | multiple interactions | ISO | Abcb1a (Mus musculus) | 6480464 | CTD | [Curcumin co-treated with Calcitriol] inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]; Calcitriol promotes the reaction [Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein]]; Curcumin inhibits the reaction [Paclitaxel results in increased expression of ABCB1 protein] | PMID:31628941 | | ||||||||||||||||||||||
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