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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708418
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cd40lg
Name: CD40 ligand
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cd40lgdecreases response to substanceISOCD40LG (Homo sapiens)6480464CTDCD40LG protein results in decreased susceptibility to PaclitaxelPMID:16545138
Cd40lgmultiple interactionsISOCD40LG (Homo sapiens)6480464CTD[Paclitaxel co-treated with Metformin] results in decreased expression of CD40LG mRNA; CD40LG protein inhibits the reaction [Paclitaxel promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]PMID:16545138 PMID:29309887
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