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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621758
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Casp12
Name: caspase 12
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13480776480464CTDPaclitaxel results in decreased expression of CASP12 protein

PMID:17701358
increases expressionISORGD:13480776480464CTDPaclitaxel results in increased expression of CASP12 protein

PMID:18098270
multiple interactionsISORGD:13480776480464CTD[Tretinoin co-treated with Paclitaxel] results in increased expression of CASP12 protein

PMID:17701358
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.