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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2451
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cycs
Name: cytochrome c, somatic
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cycsaffects localizationISOCYCS (Homo sapiens)6480464CTDPaclitaxel affects the localization of CYCS proteinPMID:17404021 PMID:18521433
Cycsincreases expressionISOCYCS (Homo sapiens)6480464CTDPaclitaxel results in increased expression of CYCS proteinPMID:15907983
Cycsincreases secretionISOCYCS (Homo sapiens)6480464CTDPaclitaxel results in increased secretion of CYCS proteinPMID:10516758
Cycsmultiple interactionsISOCYCS (Homo sapiens)6480464CTD[esculetin co-treated with Paclitaxel] affects the localization of CYCS protein; [PD168393 co-treated with Paclitaxel] affects the localization of CYCS protein; [resveratrol co-treated with Paclitaxel] affects the localization of CYCS protein; [tipifarnib co-treated with Paclitaxel] affects the localization of CYCS proteinPMID:14749477 PMID:15728126 PMID:16051289 PMID:16413505
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