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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxincreases expressionEXP 6480464CTDPaclitaxel results in increased expression of BAX mRNA; Paclitaxel results in increased expression of BAX proteinPMID:35921949 PMID:36966900
Baxmultiple interactionsEXP 6480464CTDHesperidin inhibits the reaction [Paclitaxel results in increased expression of BAX mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of BAX protein]PMID:35921949 PMID:36966900
Baxaffects response to substanceISOBax (Mus musculus)6480464CTDBAX protein affects the susceptibility to PaclitaxelPMID:17652622
Baxincreases expressionISOBax (Mus musculus)6480464CTDPaclitaxel results in increased expression of BAX mRNAPMID:17449502
Baxincreases expressionISOBAX (Homo sapiens)6480464CTD[Paclitaxel results in increased expression of TP53 protein] which results in increased expression of BAX mRNA; Paclitaxel results in increased expression of BAX mRNA; Paclitaxel results in increased expression of BAX proteinPMID:10516758 PMID:10822281 PMID:12632493 PMID:16513327 PMID:23956100 PMID:26884726 PMID:29341321 PMID:31628941 PMID:33002289 PMID:33422634 PMID:36683349 PMID:9041188
Baxmultiple interactionsISOBax (Mus musculus)6480464CTD[BAK1 protein mutant form co-treated with BAX protein mutant form] inhibits the reaction [Paclitaxel results in increased activity of and results in increased cleavage of CASP3 protein]; [glabridin co-treated with Paclitaxel] results in increased expression of BAX proteinPMID:17652622 PMID:37419298
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTD[Doxorubicin co-treated with Paclitaxel] results in increased expression of BAX protein; [esculetin co-treated with Paclitaxel] results in increased expression of BAX protein; [fisetin co-treated with Paclitaxel] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of BAX protein; [Paclitaxel co-treated with Carboplatin] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin] results in increased expression of BAX protein; [Paclitaxel co-treated with Gallic Acid] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Gallic Acid] results in increased expression of BAX protein; [Paclitaxel results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BAX protein]; [piperine analog co-treated with Paclitaxel] results in increased expression of BAX protein; Cholestanols promotes the reaction [Paclitaxel results in increased expression of BAX protein]; Curcumin promotes the reaction [Paclitaxel promotes the reaction [Calcitriol results in increased expression of BAX protein]]; Curcumin promotes the reaction [Paclitaxel results in increased expression of BAX protein]; Fluorouracil promotes the reaction [[Doxorubicin co-treated with Paclitaxel] results in increased expression of BAX protein]; Glucosides promotes the reaction [Paclitaxel results in increased expression of BAX protein]; HIF1A protein affects the reaction [IL6 protein inhibits the reaction [Paclitaxel results in increased expression of BAX protein]]; IL6 protein inhibits the reaction [Paclitaxel results in increased expression of BAX protein]; Paclitaxel promotes the reaction [Calcitriol results in increased expression of BAX protein]; Paclitaxel promotes the reaction [Cholestanols results in increased expression of BAX protein]; Paclitaxel promotes the reaction [Curcumin results in increased expression of BAX protein]; Paclitaxel promotes the reaction [Glucosides results in increased expression of BAX protein]PMID:11726273 PMID:16051289 PMID:16168113 PMID:26884726 PMID:29341321 PMID:31628941 PMID:33002289 PMID:33422634 PMID:37244399
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