GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Bax | increases expression | EXP | | 6480464 | CTD | Paclitaxel results in increased expression of BAX mRNA; Paclitaxel results in increased expression of BAX protein | PMID:35921949 PMID:36966900 | Bax | multiple interactions | EXP | | 6480464 | CTD | Hesperidin inhibits the reaction [Paclitaxel results in increased expression of BAX mRNA]; Hesperidin inhibits the reaction [Paclitaxel results in increased expression of BAX protein] | PMID:35921949 PMID:36966900 | Bax | affects response to substance | ISO | Bax (Mus musculus) | 6480464 | CTD | BAX protein affects the susceptibility to Paclitaxel | PMID:17652622 | Bax | increases expression | ISO | Bax (Mus musculus) | 6480464 | CTD | Paclitaxel results in increased expression of BAX mRNA | PMID:17449502 | Bax | increases expression | ISO | BAX (Homo sapiens) | 6480464 | CTD | [Paclitaxel results in increased expression of TP53 protein] which results in increased expression of BAX mRNA; Paclitaxel results in increased expression of BAX mRNA; Paclitaxel results in increased expression of BAX protein | PMID:10516758 PMID:10822281 PMID:12632493 PMID:16513327 PMID:23956100 PMID:26884726 PMID:29341321 PMID:31628941 PMID:33002289 PMID:33422634 PMID:36683349 PMID:9041188 | Bax | multiple interactions | ISO | Bax (Mus musculus) | 6480464 | CTD | [BAK1 protein mutant form co-treated with BAX protein mutant form] inhibits the reaction [Paclitaxel results in increased activity of and results in increased cleavage of CASP3 protein]; [glabridin co-treated with Paclitaxel] results in increased expression of BAX protein | PMID:17652622 PMID:37419298 | Bax | multiple interactions | ISO | BAX (Homo sapiens) | 6480464 | CTD | [Doxorubicin co-treated with Paclitaxel] results in increased expression of BAX protein; [esculetin co-treated with Paclitaxel] results in increased expression of BAX protein; [fisetin co-treated with Paclitaxel] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin co-treated with Gallic Acid] results in increased expression of BAX protein; [Paclitaxel co-treated with Carboplatin] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Carboplatin] results in increased expression of BAX protein; [Paclitaxel co-treated with Gallic Acid] results in increased expression of BAX mRNA; [Paclitaxel co-treated with Gallic Acid] results in increased expression of BAX protein; [Paclitaxel results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BAX protein]; [piperine analog co-treated with Paclitaxel] results in increased expression of BAX protein; Cholestanols promotes the reaction [Paclitaxel results in increased expression of BAX protein]; Curcumin promotes the reaction [Paclitaxel promotes the reaction [Calcitriol results in increased expression of BAX protein]]; Curcumin promotes the reaction [Paclitaxel results in increased expression of BAX protein]; Fluorouracil promotes the reaction [[Doxorubicin co-treated with Paclitaxel] results in increased expression of BAX protein]; Glucosides promotes the reaction [Paclitaxel results in increased expression of BAX protein]; HIF1A protein affects the reaction [IL6 protein inhibits the reaction [Paclitaxel results in increased expression of BAX protein]]; IL6 protein inhibits the reaction [Paclitaxel results in increased expression of BAX protein]; Paclitaxel promotes the reaction [Calcitriol results in increased expression of BAX protein]; Paclitaxel promotes the reaction [Cholestanols results in increased expression of BAX protein]; Paclitaxel promotes the reaction [Curcumin results in increased expression of BAX protein]; Paclitaxel promotes the reaction [Glucosides results in increased expression of BAX protein] | PMID:11726273 PMID:16051289 PMID:16168113 PMID:26884726 PMID:29341321 PMID:31628941 PMID:33002289 PMID:33422634 PMID:37244399 | |
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