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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346665
Species: Homo sapiens
RGD Object: Gene
Symbol: TNFRSF10B
Name: TNF receptor superfamily member 10b
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFRSF10Bincreases expressionEXP 6480464CTDPaclitaxel results in increased expression of TNFRSF10B proteinPMID:11212279
TNFRSF10Bmultiple interactionsEXP 6480464CTD[Paclitaxel co-treated with Metformin] results in decreased expression of TNFRSF10B mRNA; Cycloheximide inhibits the reaction [Paclitaxel results in increased expression of TNFRSF10B protein]PMID:11212279 PMID:29309887
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