GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PARP1 | affects response to substance | EXP | | 6480464 | CTD | PARP1 protein affects the susceptibility to Paclitaxel | PMID:19426673 | PARP1 | increases cleavage | EXP | | 6480464 | CTD | Paclitaxel results in increased cleavage of PARP1 protein | PMID:10075725 PMID:10430095 PMID:10502406 PMID:11774260 PMID:15492279 PMID:15585644 PMID:15907805 PMID:17404021 PMID:18071906 PMID:18451153 PMID:20610805 PMID:24126434 | PARP1 | increases expression | EXP | | 6480464 | CTD | Paclitaxel results in increased expression of PARP1 protein modified form | PMID:34272796 | PARP1 | multiple interactions | EXP | | 6480464 | CTD | [3,3'-diindolylmethane co-treated with Paclitaxel] results in increased cleavage of and results in increased activity of PARP1 protein; [Luteolin co-treated with Paclitaxel] results in decreased expression of PARP1 protein; [norcantharidin co-treated with Paclitaxel] results in increased cleavage of PARP1 protein; [piperine analog co-treated with Paclitaxel] results in increased cleavage of PARP1 protein; [Resveratrol co-treated with Paclitaxel] results in increased cleavage of PARP1 protein; [voacamine co-treated with Paclitaxel] results in increased cleavage of PARP1 protein; AKT1 protein affects the reaction [Paclitaxel results in increased cleavage of PARP1 protein]; alvocidib promotes the reaction [Paclitaxel results in increased cleavage of PARP1 protein]; CD40LG protein inhibits the reaction [Paclitaxel promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]]; MAP2K4 protein affects the reaction [Paclitaxel results in increased cleavage of PARP1 protein]; MAP3K5 protein affects the reaction [Paclitaxel results in increased cleavage of PARP1 protein]; MAPK8 protein affects the reaction [Paclitaxel results in increased cleavage of PARP1 protein]; Paclitaxel promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]; Paclitaxel promotes the reaction [norcantharidin results in increased expression of PARP1 protein modified form]; SIRT7 protein inhibits the reaction [[norcantharidin co-treated with Paclitaxel] results in increased cleavage of PARP1 protein]; TYMP inhibits the reaction [Paclitaxel results in increased cleavage of PARP1 protein]; TYMP mutant form promotes the reaction [Paclitaxel results in increased cleavage of PARP1 protein] | PMID:10075725 PMID:10430095 PMID:14749477 PMID:15492279 PMID:15907805 PMID:16545138 PMID:16580691 PMID:24525192 PMID:34272796 PMID:34856211 PMID:37244399 | PARP1 | multiple interactions | ISO | Parp1 (Mus musculus) | 6480464 | CTD | [rottlerin co-treated with Paclitaxel] results in increased cleavage of PARP1 protein | PMID:35995259 | | ||||||||||||||||||||||
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