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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1343608
Species: Homo sapiens
RGD Object: Gene
Symbol: ITGAM
Name: integrin subunit alpha M
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ITGAMincreases expressionISOItgam (Rattus norvegicus)6480464CTDPaclitaxel results in increased expression of ITGAM mRNAPMID:17174526
ITGAMmultiple interactionsISOItgam (Mus musculus)6480464CTDITGAM protein affects the reaction [Paclitaxel affects the localization of and results in increased activity of [NFKB1 protein binds to RELA protein]]; ITGAM protein affects the reaction [Paclitaxel results in increased expression of IL12A mRNA]; ITGAM protein affects the reaction [Paclitaxel results in increased expression of PTGS2 mRNA]; ITGAM protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK1 protein]; ITGAM protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK3 protein]; ITGAM protein affects the reaction [Paclitaxel results in increased phosphorylation of MAPK8 protein]; ITGAM protein affects the reaction [Paclitaxel results in increased secretion of [IL12A protein binds to IL12B protein]]PMID:11123339
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