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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1315462
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCC10
Name: ATP binding cassette subfamily C member 10
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCC10decreases response to substanceEXP 6480464CTDABCC10 protein results in decreased susceptibility to PaclitaxelPMID:19841739
ABCC10increases expressionEXP 6480464CTDPaclitaxel results in increased expression of ABCC10 mRNAPMID:20737486
ABCC10multiple interactionsEXP 6480464CTDABCC10 protein results in decreased abundance of and results in increased secretion of Paclitaxel; Imatinib Mesylate inhibits the reaction [ABCC10 protein results in decreased abundance of and results in increased secretion of Paclitaxel]; Imatinib Mesylate inhibits the reaction [ABCC10 protein results in decreased susceptibility to Paclitaxel]; nilotinib inhibits the reaction [ABCC10 protein results in decreased abundance of and results in increased secretion of Paclitaxel]; nilotinib inhibits the reaction [ABCC10 protein results in decreased susceptibility to Paclitaxel]PMID:19841739
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