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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 11476
Species: Mus musculus
RGD Object: Gene
Symbol: Ugt1a1
Name: UDP glucuronosyltransferase 1 family, polypeptide A1
Acc ID: CHEBI:45863
Term: paclitaxel
Definition: A tetracyclic diterpenoid isolated originally from the bark of the Pacific yew tree, Taxus brevifolia. It is a mitotic inhibitor used in cancer chemotherapy. Note that the use of the former generic name 'taxol' is now limited, as Taxol is a registered trade mark.
Chemical ID: MESH:D017239
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a1increases expressionEXP 6480464CTDPaclitaxel results in increased expression of UGT1A1 mRNA; Paclitaxel results in increased expression of UGT1A1 proteinPMID:28242239
Ugt1a1multiple interactionsEXP 6480464CTDTLR4 protein mutant form inhibits the reaction [Paclitaxel results in increased expression of UGT1A1 mRNA]; TLR4 protein mutant form inhibits the reaction [Paclitaxel results in increased expression of UGT1A1 protein]PMID:28242239
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