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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 736832
Species: Homo sapiens
RGD Object: Gene
Symbol: EGF
Name: epidermal growth factor
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EGFincreases expressionEXP 6480464CTDvorinostat results in increased expression of EGF mRNAPMID:27188386
EGFmultiple interactionsEXP 6480464CTD[NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of EGF mRNAPMID:27188386
EGFdecreases response to substanceISOEgf (Mus musculus)6480464CTDvorinostat results in decreased susceptibility to EGF proteinPMID:22749963
EGFmultiple interactionsISOEgf (Mus musculus)6480464CTDvorinostat inhibits the reaction [EGF protein results in increased expression of CCND1 protein]PMID:22749963
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