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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734300
Species: Mus musculus
RGD Object: Gene
Symbol: Bcl2l11
Name: BCL2 like 11
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcl2l11increases expressionISOBcl2l11 (Rattus norvegicus)6480464CTDvorinostat results in increased expression of BCL2L11 mRNA; vorinostat results in increased expression of BCL2L11 proteinPMID:17331788
Bcl2l11increases expressionISOBCL2L11 (Homo sapiens)6480464CTDvorinostat results in increased expression of BCL2L11 mRNA; vorinostat results in increased expression of BCL2L11 protein; vorinostat results in increased expression of BCL2L11 protein alternative formPMID:16144943 PMID:17351739 PMID:19509267 PMID:21652541
Bcl2l11multiple interactionsISOBCL2L11 (Homo sapiens)6480464CTD[NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of BCL2L11 mRNA; TNFSF10 protein promotes the reaction [Vorinostat results in increased expression of BCL2L11 mRNA]; TNFSF10 protein promotes the reaction [Vorinostat results in increased expression of BCL2L11 protein]PMID:19509267 PMID:27188386
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