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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Jundecreases expressionISOJUN (Homo sapiens)6480464CTDvorinostat results in decreased expression of JUN mRNAPMID:27188386
Jundecreases phosphorylationISOJUN (Homo sapiens)6480464CTDvorinostat results in decreased phosphorylation of JUN proteinPMID:20531243
Junincreases expressionISOJUN (Homo sapiens)6480464CTDvorinostat results in increased expression of JUN proteinPMID:10597302
Junincreases phosphorylationISOJUN (Homo sapiens)6480464CTDvorinostat results in increased phosphorylation of JUN proteinPMID:10597302
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