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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1606342
Species: Homo sapiens
RGD Object: Gene
Symbol: FASLG
Name: Fas ligand
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FASLGincreases expressionEXP 6480464CTDvorinostat results in increased expression of FASLG mRNA; vorinostat results in increased expression of FASLG proteinPMID:17351739 PMID:18025281 PMID:19737941
FASLGmultiple interactionsEXP 6480464CTD[Bortezomib co-treated with Vorinostat] results in increased expression of FASLG mRNA; [Bortezomib co-treated with Vorinostat] results in increased expression of FASLG protein; Curcumin inhibits the reaction [[Vorinostat co-treated with Bortezomib] results in increased expression of FASLG protein]PMID:17351739
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