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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1563028
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Appl2
Name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:16056536480464CTDvorinostat results in decreased expression of APPL2 mRNA

PMID:27188386
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