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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1558155
Species: Mus musculus
RGD Object: Gene
Symbol: H2ax
Name: H2A.X variant histone
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2axincreases activityISOH2AX (Homo sapiens)6480464CTDVorinostat results in increased activity of H2AX proteinPMID:20460513
H2axincreases expressionISOH2AX (Homo sapiens)6480464CTDVorinostat results in increased expression of H2AX protein; Vorinostat results in increased expression of H2AX protein modified formPMID:20679231 PMID:22923501
H2axincreases phosphorylationISOH2AX (Homo sapiens)6480464CTDVorinostat results in increased phosphorylation of H2AX proteinPMID:20531243
H2axmultiple interactionsISOH2AX (Homo sapiens)6480464CTDResveratrol promotes the reaction [Vorinostat results in increased expression of H2AX protein]PMID:22923501
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