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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1552484
Species: Mus musculus
RGD Object: Gene
Symbol: Bbc3
Name: BCL2 binding component 3
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bbc3increases expressionISOBBC3 (Homo sapiens)6480464CTDvorinostat results in increased expression of BBC3 mRNA; vorinostat results in increased expression of BBC3 proteinPMID:19509267 PMID:21527555
Bbc3multiple interactionsISOBBC3 (Homo sapiens)6480464CTDTNFSF10 protein promotes the reaction [vorinostat results in increased expression of BBC3 mRNA]; TNFSF10 protein promotes the reaction [vorinostat results in increased expression of BBC3 protein]PMID:19509267
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