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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359550
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Sp100
Name: SP100 nuclear antigen
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionISORGD:13481006480464CTDvorinostat results in increased expression of SP100 mRNA

PMID:27188386
multiple interactionsISORGD:13481006480464CTDvorinostat promotes the reaction [PML protein binds to SP100 protein]

PMID:19631782
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.