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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1350006
Species: Homo sapiens
RGD Object: Gene
Symbol: UGT2B17
Name: UDP glucuronosyltransferase family 2 member B17
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
UGT2B17increases glucuronidationEXP 6480464CTDUGT2B17 protein results in increased glucuronidation of vorinostatPMID:25393417
UGT2B17multiple interactionsEXP 6480464CTD[Warfarin binds to and results in decreased activity of UGT2B17 protein] which results in decreased glucuronidation of Vorinostat; Warfarin inhibits the reaction [UGT2B17 protein results in increased glucuronidation of Vorinostat]PMID:25393417
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