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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1347209
Species: Homo sapiens
RGD Object: Gene
Symbol: BIRC2
Name: baculoviral IAP repeat containing 2
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
BIRC2multiple interactionsEXP 6480464CTD[vorinostat co-treated with TNFSF10 protein] results in decreased expression of BIRC2 protein; vorinostat inhibits the reaction [TNF protein results in increased expression of BIRC2 protein]PMID:16377638 PMID:19643600
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