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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10940
Species: Mus musculus
RGD Object: Gene
Symbol: Myc
Name: myelocytomatosis oncogene
Acc ID: CHEBI:45716
Term: vorinostat
Definition: A dicarboxylic acid diamide comprising suberic (octanedioic) acid coupled to aniline and hydroxylamine. A histone deacetylase inhibitor, it is marketed under the name Zolinza for the treatment of cutaneous T cell lymphoma (CTCL).
Chemical ID: MESH:C111237
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mycdecreases expressionISOMYC (Homo sapiens)6480464CTDvorinostat results in decreased expression of MYC mRNA; vorinostat results in decreased expression of MYC proteinPMID:10597302 PMID:17417771 PMID:19440035 PMID:24930440
Mycmultiple interactionsISOMyc (Rattus norvegicus)6480464CTD[vorinostat co-treated with MYC protein] results in decreased expression of BCL2 mRNA; [vorinostat co-treated with MYC protein] results in decreased expression of BCL2 protein; [vorinostat co-treated with MYC protein] results in decreased expression of BCL2L1 mRNA; [vorinostat co-treated with MYC protein] results in decreased expression of BCL2L1 protein; [vorinostat co-treated with MYC protein] results in increased activity of BAX protein; [vorinostat co-treated with MYC protein] results in increased activity of CASP3 protein; [vorinostat co-treated with MYC protein] results in increased cleavage of CASP9 proteinPMID:17331788
Mycmultiple interactionsISOMYC (Homo sapiens)6480464CTD[17-(dimethylaminoethylamino)-17-demethoxygeldanamycin co-treated with Vorinostat] results in decreased expression of MYC protein; [Decitabine co-treated with Vorinostat] results in decreased expression of MYC protein; [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of MYC mRNA; Vorinostat inhibits the reaction [TNF protein results in increased expression of MYC protein]PMID:16377638 PMID:17417771 PMID:19440035 PMID:27188386
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