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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732175
Species: Mus musculus
RGD Object: Gene
Symbol: Bche
Name: butyrylcholinesterase
Acc ID: CHEBI:45652
Term: succinylcholine
Definition: A quaternary ammonium ion that is the bis-choline ester of succinic acid.
Chemical ID: MESH:D013390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Bcheaffects hydrolysisISORGD:7321746480464CTDBCHE protein mutant form affects the hydrolysis of Succinylcholine

PMID:18555211
Bcheaffects response to substanceISORGD:7321746480464CTDBCHE affects the susceptibility to Succinylcholine BCHE gene mutant form affects the susceptibility to Succinylcholine BCHE gene polymorphism affects the susceptibility to Succinylcholine BCHE protein affects the susceptibility to Succinylcholine

PMID:15688329 PMID:16788378 PMID:16884476 PMID:18075469 PMID:18399847 PMID:9110359
Bchedecreases abundanceISORGD:7321746480464CTDBCHE protein results in decreased abundance of Succinylcholine

PMID:5412891
Bchedecreases hydrolysisISORGD:7321746480464CTDBCHE protein mutant form results in decreased hydrolysis of Succinylcholine

PMID:4985882
Bcheincreases hydrolysisISORGD:7321746480464CTDBCHE protein results in increased hydrolysis of Succinylcholine

PMID:18555211 PMID:4985882 PMID:4998912
Bcheincreases metabolic processingISORGD:7321746480464CTDBCHE protein results in increased metabolism of Succinylcholine

PMID:12190811 PMID:21228368 PMID:2249680 PMID:2432808 PMID:25054547
Bcheincreases response to substanceISORGD:7321746480464CTDBCHE gene mutant form results in increased susceptibility to Succinylcholine BCHE gene polymorphism results in increased susceptibility to Succinylcholine BCHE protein mutant form results in increased susceptibility to Succinylcholine

PMID:1058931 PMID:1147298 PMID:1218148 PMID:1218179 PMID:12881446 PMID:15826794 PMID:1734774 PMID:1781528 PMID:21029050 PMID:25054547 PMID:4319258 PMID:4698763 PMID:4728581 PMID:4746059 PMID:4850696 PMID:4998912 PMID:5365519 PMID:5488351 PMID:5673118 PMID:6465587 PMID:6859614 PMID:6928942 PMID:7069741 PMID:726855 PMID:7294376 PMID:7378868 PMID:7793179 PMID:8179139 PMID:900467 PMID:987736
Bchemultiple interactionsISORGD:7321746480464CTD[Dichlorvos results in decreased activity of BCHE protein] which results in increased susceptibility to Succinylcholine Insecticides inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine] Organophosphorus Compounds inhibits the reaction [BCHE protein results in increased metabolism of Succinylcholine] Succinylcholine inhibits the reaction [BCHE protein results in increased hydrolysis of butyrylcholine]

PMID:12190811 PMID:2432808 PMID:4985882
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