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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1353273
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2A7
Name: cytochrome P450 family 2 subfamily A member 7
Acc ID: CHEBI:4562
Term: dihydroergotamine
Definition: Ergotamine in which a single bond replaces the double bond between positions 9 and 10. A semisynthetic ergot alkaloid with weaker oxytocic and vasoconstrictor properties than ergotamine, it is used (as the methanesulfonic or tartaric acid salts) for the treatment of migraine and orthostatic hypotension.
Chemical ID: MESH:D004087
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2A7decreases activityISOCyp2a4 (Mus musculus)6480464CTDDihydroergotamine results in decreased activity of CYP2A4 proteinPMID:18420780
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