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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3701
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Slc22a3
Name: solute carrier family 22 member 3
Acc ID: CHEBI:4551
Term: digoxin
Definition: A cardenolide glycoside that is digitoxin beta-hydroxylated at C-12. A cardiac glycoside extracted from the foxglove plant, Digitalis lanata, it is used to control ventricular rate in atrial fibrillation and in the management of congestive heart failure with atrial fibrillation, but the margin between toxic and therapeutic doses is small.
Chemical ID: MESH:D004077
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Slc22a3multiple interactionsISOSLC22A3 (Homo sapiens)6480464CTDDigoxin inhibits the reaction [SLC22A3 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]PMID:21641380
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