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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734103
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1H4
Name: nuclear receptor subfamily 1 group H member 4
Acc ID: CHEBI:45285
Term: pyrazinecarboxamide
Definition: A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of pyrazinoic acid (pyrazine-2-carboxylic acid) with ammonia. A prodrug for pyrazinoic acid, pyrazinecarboxamide is used as part of multidrug regimens for the treatment of tuberculosis.
Chemical ID: MESH:D011718
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1H4multiple interactionsEXP 6480464CTD[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of NR1H4PMID:35835356
NR1H4decreases expressionISONr1h4 (Rattus norvegicus)6480464CTDPyrazinamide results in decreased expression of NR1H4 mRNA; Pyrazinamide results in decreased expression of NR1H4 proteinPMID:27255380
NR1H4multiple interactionsISONr1h4 (Rattus norvegicus)6480464CTD[Isoniazid co-treated with Rifampin co-treated with Pyrazinamide co-treated with Ethambutol] affects the expression of NR1H4; obeticholic acid inhibits the reaction [Pyrazinamide results in decreased expression of NR1H4 mRNA]PMID:27255380 PMID:35835356
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