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RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:4518
Term: dienestrol
Definition: An olefinic compound that is hexa-2,4-diene substituted by 4-hydroxyphenyl groups at positions 3 and 4 respectively.
Chemical ID: MESH:D004028
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingISORGD:7365596480464CTDDienestrol binds to ESR1 protein

Esr1decreases activityISORGD:7365596480464CTDDienestrol results in decreased activity of ESR1 protein

Esr1multiple interactionsISORGD:7365596480464CTDDienestrol binds to and results in increased activity of ESR1 protein, Dienestrol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein], Dienestrol promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]

PMID:15026083, PMID:18976723, PMID:19233257, PMID:25012808, PMID:9048584
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.