Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2581
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr1
Name: estrogen receptor 1
Acc ID: CHEBI:4518
Term: dienestrol
Definition: An olefinic compound that is hexa-2,4-diene substituted by 4-hydroxyphenyl groups at positions 3 and 4 respectively.
Chemical ID: MESH:D004028
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr1affects bindingISORGD:7365596480464CTDDienestrol binds to ESR1 protein

PMID:19233257
Esr1decreases activityISORGD:7365596480464CTDDienestrol results in decreased activity of ESR1 protein

PMID:25012808
Esr1multiple interactionsISORGD:7365596480464CTDDienestrol binds to and results in increased activity of ESR1 protein, Dienestrol inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein], Dienestrol promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form]

PMID:15026083, PMID:18976723, PMID:19233257, PMID:25012808, PMID:9048584
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.