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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 621061
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Kat5
Name: lysine acetyltransferase 5
Acc ID: CHEBI:45081
Term: pentamidine
Definition: A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
Chemical ID: MESH:D010419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kat5decreases activityISORGD:7323546480464CTDPentamidine results in decreased activity of KAT5 protein

PMID:20144237
Kat5multiple interactionsISORGD:7323546480464CTDPentamidine inhibits the reaction [KAT5 protein results in increased acetylation of TP53 protein]

PMID:20144237
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