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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1593265
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atm
Name: ATM serine/threonine kinase
Acc ID: CHEBI:45081
Term: pentamidine
Definition: A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
Chemical ID: MESH:D010419
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atmaffects localizationISORGD:16060406480464CTDPentamidine affects the localization of ATM protein modified form

PMID:20144237
Atmdecreases activityISORGD:16060406480464CTDPentamidine results in decreased activity of ATM protein

PMID:20144237
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