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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730935
Species: Homo sapiens
RGD Object: Gene
Symbol: HIF1A
Name: hypoxia inducible factor 1 subunit alpha
Acc ID: CHEBI:44975
Term: 1,10-phenanthroline
Definition: A phenanthroline that has formula 180.20540.
Chemical ID: MESH:C025205
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HIF1Aincreases activityEXP 6480464CTD1,10-phenanthroline results in increased activity of HIF1A proteinPMID:19502547
HIF1Amultiple interactionsEXP 6480464CTD4'-O-methylalpinumisoflavone inhibits the reaction [1,10-phenanthroline deficiency results in increased activity of HIF1A protein]; alpinumisoflavone inhibits the reaction [1,10-phenanthroline deficiency results in increased activity of HIF1A protein]PMID:19091749
HIF1Amultiple interactionsISOHif1a (Mus musculus)6480464CTDHIF1A protein promotes the reaction [1,10-phenanthroline results in increased expression of VEGFA protein]PMID:19502547
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