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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 733705
Species: Homo sapiens
RGD Object: Gene
Symbol: CTNNB1
Name: catenin beta 1
Acc ID: CHEBI:4495
Term: diazoxide
Definition: A benzothiadiazine that is the S,S-dioxide of 2H-1,2,4-benzothiadiazine which is substituted at position 3 by a methyl group and at position 7 by chlorine. A peripheral vasodilator, it increases the concentration of glucose in the plasma and inhibits the secretion of insulin by the beta- cells of the pancreas. It is used orally in the management of intractable hypoglycaemia and intravenously in the management of hypertensive emergencies.
Chemical ID: MESH:D003981
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CTNNB1decreases expressionEXP 6480464CTDDiazoxide results in decreased expression of CTNNB1 proteinPMID:19052819
CTNNB1multiple interactionsEXP 6480464CTDDiazoxide inhibits the reaction [CTNNB1 protein results in increased activity of CCND1 promoter]PMID:19052819
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