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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 732909
Species: Homo sapiens
RGD Object: Gene
Symbol: AKT1
Name: AKT serine/threonine kinase 1
Acc ID: CHEBI:44915
Term: propofol
Definition: A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Chemical ID: MESH:D015742
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKT1decreases phosphorylationEXP 6480464CTDPropofol results in decreased phosphorylation of AKT1 proteinPMID:35238236
AKT1multiple interactionsEXP 6480464CTDCASC9 protein inhibits the reaction [Propofol results in decreased phosphorylation of AKT1 protein]PMID:35238236
AKT1increases phosphorylationISOAkt1 (Rattus norvegicus)6480464CTDPropofol results in increased phosphorylation of AKT1 proteinPMID:24810525
AKT1multiple interactionsISOAkt1 (Rattus norvegicus)6480464CTDPropofol promotes the reaction [Streptozocin results in decreased phosphorylation of AKT1 protein]PMID:24810525
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