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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2192
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Bax
Name: BCL2 associated X, apoptosis regulator
Acc ID: CHEBI:44915
Term: propofol
Definition: A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Chemical ID: MESH:D015742
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Baxdecreases expressionEXP 6480464CTDPropofol results in decreased expression of BAXPMID:23353162
Baxmultiple interactionsEXP 6480464CTD[resveratrol co-treated with Propofol] results in decreased expression of BAX; Propofol inhibits the reaction [Doxorubicin results in increased expression of BAX protein]PMID:22015447 PMID:23353162
Baxincreases expressionISOBax (Mus musculus)6480464CTDPropofol results in increased expression of BAX proteinPMID:21786383
Baxincreases expressionISOBAX (Homo sapiens)6480464CTDPropofol results in increased expression of BAX proteinPMID:28804952
Baxmultiple interactionsISOBAX (Homo sapiens)6480464CTDAcetylcysteine inhibits the reaction [Propofol results in increased expression of BAX protein]PMID:28804952
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