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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1348090
Species: Homo sapiens
RGD Object: Gene
Symbol: UGT1A9
Name: UDP glucuronosyltransferase family 1 member A9
Acc ID: CHEBI:44915
Term: propofol
Definition: A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Chemical ID: MESH:D015742
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
UGT1A9affects metabolic processingEXP 6480464CTDUGT1A9 protein affects the metabolism of PropofolPMID:15286053
UGT1A9decreases activityEXP 6480464CTDPropofol results in decreased activity of UGT1A9 proteinPMID:15378558
UGT1A9increases glucuronidationEXP 6480464CTDUGT1A9 protein results in increased glucuronidation of PropofolPMID:12756209 PMID:14570768 PMID:15769885 PMID:15988124 PMID:18816295 PMID:25393417 PMID:26875642 PMID:31128210
UGT1A9multiple interactionsEXP 6480464CTD[Warfarin binds to and affects the activity of UGT1A9 protein] which affects the glucuronidation of Propofol; licochalcone A inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]; shikonin inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]; Warfarin affects the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]PMID:25393417 PMID:26875642 PMID:31128210
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