GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | UGT1A9 | affects metabolic processing | EXP | | 6480464 | CTD | UGT1A9 protein affects the metabolism of Propofol | PMID:15286053 | UGT1A9 | decreases activity | EXP | | 6480464 | CTD | Propofol results in decreased activity of UGT1A9 protein | PMID:15378558 | UGT1A9 | increases glucuronidation | EXP | | 6480464 | CTD | UGT1A9 protein results in increased glucuronidation of Propofol | PMID:12756209 PMID:14570768 PMID:15769885 PMID:15988124 PMID:18816295 PMID:25393417 PMID:26875642 PMID:31128210 | UGT1A9 | multiple interactions | EXP | | 6480464 | CTD | [Warfarin binds to and affects the activity of UGT1A9 protein] which affects the glucuronidation of Propofol; licochalcone A inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]; shikonin inhibits the reaction [UGT1A9 protein results in increased glucuronidation of Propofol]; Warfarin affects the reaction [UGT1A9 protein results in increased glucuronidation of Propofol] | PMID:25393417 PMID:26875642 PMID:31128210 | |
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