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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1342708
Species: Homo sapiens
RGD Object: Gene
Symbol: UGT1A8
Name: UDP glucuronosyltransferase family 1 member A8
Acc ID: CHEBI:44915
Term: propofol
Definition: A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Chemical ID: MESH:D015742
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
UGT1A8decreases activityEXP 6480464CTDPropofol results in decreased activity of UGT1A8 proteinPMID:15378558
UGT1A8multiple interactionsEXP 6480464CTDPropofol promotes the reaction [UGT1A8 protein results in increased glucuronidation of Hymecromone]PMID:15378558
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