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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 10614
Species: Mus musculus
RGD Object: Gene
Symbol: Gabrb3
Name: GABRB3, gamma-aminobutyric acid type A receptor subunit beta 3
Acc ID: CHEBI:44915
Term: propofol
Definition: A phenol resulting from the formal substitution of the hydrogen at the 2 position of 1,3-diisopropylbenzene by a hydroxy group.
Chemical ID: MESH:D015742
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Gabrb3multiple interactionsISOGABRB3 (Homo sapiens)6480464CTD[Propofol co-treated with Pentobarbital] promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; delta-hexachlorocyclohexane inhibits the reaction [Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]]; Propofol affects the reaction [Flunitrazepam binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol affects the reaction [Muscimol binds to [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol promotes the reaction [gamma-Aminobutyric Acid results in increased activity of [GABRA1 protein binds to GABRB3 protein binds to GABRG2 protein]]; Propofol results in increased activity of [GABRA1 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3 binds to GABRG2 protein alternative form]; Propofol results in increased activity of [GABRA2 protein binds to GABRB3]; Propofol results in increased activity of [GABRA6 protein binds to GABRB3 binds to GABRG2 protein alternative form]PMID:22029276 PMID:29038840 PMID:9316872
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