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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 735868
Species: Homo sapiens
RGD Object: Gene
Symbol: NQO1
Name: NAD(P)H quinone dehydrogenase 1
Acc ID: CHEBI:4488
Term: diallyl disulfide
Definition: An organic disulfide where the organic group specified is allyl. It has been isolated from garlic and other species of the genus Allium.
Chemical ID: MESH:C028009
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases activityISORGD:25036480464CTDdiallyl disulfide results in increased activity of NQO1 protein

PMID:8339252
multiple interactionsISORGD:25036480464CTDdiallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 mRNA], diallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of NQO1 protein]

PMID:24293383
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.