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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 734432
Species: Mus musculus
RGD Object: Gene
Symbol: Nfe2l2
Name: nuclear factor, erythroid derived 2, like 2
Acc ID: CHEBI:4488
Term: diallyl disulfide
Definition: An organic disulfide where the organic group specified is allyl. It has been isolated from garlic and other species of the genus Allium.
Chemical ID: MESH:C028009
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfe2l2decreases degradationEXP 6480464CTDdiallyl disulfide results in decreased degradation of NFE2L2 proteinPMID:34896185
Nfe2l2decreases expressionEXP 6480464CTDdiallyl disulfide results in decreased expression of NFE2L2 mRNAPMID:34896185
Nfe2l2multiple interactionsEXP 6480464CTDdiallyl disulfide affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NFE2L2 protein]; diallyl disulfide inhibits the reaction [Ethanol affects the expression of NFE2L2 protein]; diallyl disulfide results in increased expression of and affects the localization of NFE2L2 protein; NFE2L2 protein affects the reaction [diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of GCLC mRNA]]; NFE2L2 protein affects the reaction [diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of NQO1 mRNA]]; NFE2L2 protein affects the reaction [diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]]; NFE2L2 protein affects the reaction [diallyl disulfide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of GCLM mRNA]]; NFE2L2 protein affects the reaction [diallyl disulfide promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HMOX1 mRNA]]PMID:34896185 PMID:35526736
Nfe2l2multiple interactionsISONfe2l2 (Rattus norvegicus)6480464CTDdiallyl disulfide inhibits the reaction [Carbon Tetrachloride results in decreased expression of and affects the localization of NFE2L2 protein]PMID:24293383
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