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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730951
Species: Homo sapiens
RGD Object: Gene
Symbol: NOS2
Name: nitric oxide synthase 2
Acc ID: CHEBI:4488
Term: diallyl disulfide
Definition: An organic disulfide where the organic group specified is allyl. It has been isolated from garlic and other species of the genus Allium.
Chemical ID: MESH:C028009
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS2affects expressionEXP 6480464CTDdiallyl disulfide affects the expression of NOS2 proteinPMID:21695758
NOS2multiple interactionsISONos2 (Mus musculus)6480464CTDdiallyl disulfide inhibits the reaction [[Ethanol co-treated with Lipopolysaccharides] results in increased expression of NOS2 protein]; diallyl disulfide inhibits the reaction [Ethanol results in increased expression of NOS2 protein]; diallyl disulfide inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]PMID:34896185 PMID:35526736
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