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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 738048
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mrgprx2
Name: MAS related GPR family member X2
Acc ID: CHEBI:4470
Term: dextromethorphan
Definition: A 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough.
Chemical ID: MESH:D003915
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Mrgprx2affects bindingISORGD:16032806480464CTDDextromethorphan binds to MRGPRX2 protein

PMID:32871113
Mrgprx2affects response to substanceISORGD:16032806480464CTDMRGPRX2 protein affects the susceptibility to Dextromethorphan

PMID:32871113
Mrgprx2multiple interactionsISORGD:16032806480464CTDMRGPRX2 protein affects the reaction [Dextromethorphan results in increased secretion of HEXB protein]

PMID:32871113
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