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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 708427
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Cyp2d1
Name: cytochrome P450, family 2, subfamily d, polypeptide 1
Acc ID: CHEBI:4470
Term: dextromethorphan
Definition: An organic heterotetracyclic compound that is morphinan substituted by a methoxy group at position 3 and a methyl group at position 7. It is used as an antitussive drug for suppressing cough.
Chemical ID: MESH:D003915
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases metabolic processingISORGD:16233196480464CTDCYP2D10 protein results in increased metabolism of Dextromethorphan

PMID:30503582
multiple interactionsISORGD:16233196480464CTD[CYP2D10 protein results in increased metabolism of Dextromethorphan] which results in increased chemical synthesis of Dextrorphan

PMID:30503582
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.