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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69426
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Oprk1
Name: opioid receptor, kappa 1
Acc ID: CHEBI:4470
Term: dextromethorphan
Definition: A 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough.
Chemical ID: MESH:D003915
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Oprk1affects bindingEXP 6480464CTDDextromethorphan binds to OPRK1 protein

PMID:7562497
Oprk1multiple interactionsEXP 6480464CTD[Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Norepinephrine [Dextromethorphan binds to OPRK1 protein] which results in decreased uptake of Serotonin

PMID:7562497
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