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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2943
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Jun
Name: Jun proto-oncogene, AP-1 transcription factor subunit
Acc ID: CHEBI:4470
Term: dextromethorphan
Definition: A 6-methoxy-11-methyl-1,3,4,9,10,10a-hexahydro-2H-10,4a-(epiminoethano)phenanthrene in which the sterocenters at positions 4a, 10 and 10a have S-configuration. It is a prodrug of dextrorphan and used as an antitussive drug for suppressing cough.
Chemical ID: MESH:D003915
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Junmultiple interactionsEXP 6480464CTDDextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA] Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein] N-2-3 4-Dichlorphenylethyl-N N' N'-trimethyl-1 2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]] N-2-3 4-Dichlorphenylethyl-N N' N'-trimethyl-1 2-ethandiamin inhibits the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]] SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN mRNA]] SIGMAR1 protein affects the reaction [Dextromethorphan inhibits the reaction [Kainic Acid results in increased expression of JUN protein]]

PMID:15723099
Junmultiple interactionsISORGD:108286480464CTDDextromethorphan inhibits the reaction [3-Pyridinecarboxylic acid 1 4-dihydro-2 6-dimethyl-5-nitro-4-2-trifluoromethylphenyl-, Methyl ester results in increased expression of JUN]

PMID:15084442
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