Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 730901
Species: Homo sapiens
RGD Object: Gene
Symbol: HMOX1
Name: heme oxygenase 1
Acc ID: CHEBI:4466
Term: dexmedetomidine
Definition: A medetomidine that has formula C13H16N2.
Chemical ID: MESH:D020927
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HMOX1multiple interactionsEXP 6480464CTDDexmedetomidine promotes the reaction [Ropivacaine results in increased expression of HMOX1 protein]; NFE2L2 protein promotes the reaction [Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of HMOX1 protein]]; zinc protoporphyrin inhibits the reaction [Dexmedetomidine promotes the reaction [Ropivacaine results in increased expression of HMOX1 protein]]PMID:36858639
HMOX1increases expressionISOHmox1 (Rattus norvegicus)6480464CTDDexmedetomidine results in increased expression of HMOX1 mRNAPMID:36027947
HMOX1multiple interactionsISOHmox1 (Rattus norvegicus)6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of and results in decreased activity of HMOX1 protein]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of HMOX1 mRNA]]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of HMOX1 protein]]; atipamezole inhibits the reaction [Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of HMOX1 protein]]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of and results in decreased activity of HMOX1 protein]; Dexmedetomidine inhibits the reaction [Isoflurane results in decreased expression of HMOX1 mRNA]; Dexmedetomidine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of HMOX1 protein]; Dexmedetomidine results in increased expression of and results in increased activity of HMOX1 proteinPMID:30597158 PMID:36027947
Go Back to source page   Continue to Ontology report